Journal article
What happens after menopause? (WHAM): A prospective controlled study of symptom profiles up to 12 months after pre-menopausal risk-reducing salpingo-oophorectomy
Katrina M Moss, Gita D Mishra, Efrosinia O Krejany, Martha Hickey
GYNECOLOGIC ONCOLOGY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2022
Abstract
Objective. Understanding how symptoms cluster after premenopausal risk-reducing salpingo-oophorectomy (RRSO) can inform patient expectations but information is lacking. We aimed to identify symptom profiles after RRSO, changes over time, and the effect of hormone therapy (HT). Method. Participants were premenopausal women from a longitudinal controlled study (What Happens After Menopause? (WHAM)). Menopausal symptoms were prospectively measured in three groups: pre-menopausal comparisons who retained their ovaries (n = 99), RRSO HT users (n = 57) and RRSO non-HT users (n = 38). Symptoms (hot flashes, night sweats, low desire, vaginal dryness, poor sleep, anxiety/depression) were measured at ..
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Funding Acknowledgements
This research was supported by Register4 through its members'par-ticipation in research and/or provision of samples and information (http://register4.org.au) . We are grateful to the women who generously gave of their time to participate in this study and to the following people who assisted with participant recruitment and study management: David Wrede, Orla McNally and Deborah Neesham (The Royal Women's Hospital, Melbourne) ; Judy Kirk and Alison Brand (Westmead Hospital, Sydney) ; Lesley Andrews and Leon Botes (Prince of Wales Hospital, Sydney) ; Bettina Meiser (University of New South Wales, Sydney, Australia) ; Mariana De Sousa (University of Technology, Sydney) ; Heather Symecko (University of Pennsylvania, Philadelphia) ; Alison Trainer, Sue Shanley, Gillian Mitchell and Mary Shanahan (Peter MacCallum Cancer Centre, Melbourne) ; Trevor Tejada-Berges and Masako Dunn (Chris O'Brien Lifehouse, Sydney, Australia) ; L. Jane McNeilage and Marion Harris (Monash Medical Centre, Melbourne, Australia) ; Geoffrey Lindeman (The Royal Melbourne Hospital, Melbourne) ; Peter Grant (Mercy Hospital for Women, Melbourne) and Nipuni Gamage (University of Melbourne, Melbourne) . Thanks also to Mary-Ann Davey (Monash University, Melbourne, Australia) and Sabine Braat (The University of Melbourne, Australia) for the provision of preliminary advice and support with statistical methodology and analysis.